Kwakwalwa tana sarrafa lysophospholipids na jikin mu, wanda hakan yana sarrafa shirin da ke kunna ci abinci mai gina jiki / takamaiman masu hana haɓakar lipid na iya zama sabbin hanyoyin kwantar da kiba / bugawa a cikin 'Nature Metabolism'.
Ƙungiyar masu bincike sun ƙirƙiri wata sabuwar hanya gaba ɗaya don magance matsalar cin abinci. Masanan kimiyya sun nuna cewa rukuni na kwayoyin jijiyoyi a cikin hypothalamus (wanda ake kira AgRP, peptide neurons da ke da alaka da agouti) suna sarrafa sakin lysophospholipids na endogenous, wanda hakan ke sarrafa tashin hankali na jijiyoyi a cikin kwakwalwar kwakwalwa, wanda ke motsa abinci.
A cikin wannan tsari, muhimmin mataki na hanyar siginar yana sarrafawa ta hanyar enzyme autotaxin, wanda ke da alhakin samar da acid lysophosphatidic (LPA) a cikin kwakwalwa a matsayin mai daidaita ayyukan cibiyar sadarwa.
The gwamnati na masu hana autotaxin na iya rage yawan cin abinci da yawa bayan azumi da kiba a cikin samfuran dabbobi. Labarin 'AgRP neurons suna sarrafa halayen cin abinci a cortical synapses ta hanyar lysophospholipids da aka samo asali' yanzu ya bayyana a cikin Nature Metabolism.
Rashin cin abinci musamman kiba na daya daga cikin abubuwan da ke haifar da cututtuka iri-iri a cikin al'ummomin da ke da masana'antu a duk duniya, musamman cututtukan zuciya da jijiyoyin jini masu nakasa na dindindin ko kuma sakamakon kisa kamar bugun zuciya, ciwon sukari, ko bugun jini.
Cibiyar Robert Koch ta ruwaito a cikin 2021 cewa kashi 67 na maza da kashi 53 na mata a Jamus suna da kiba. Kashi 23 na manya suna da kiba sosai (kiba). Ƙoƙarin rinjayar halin cin abinci tare da magunguna ya zuwa yanzu bai yi tasiri ba.
Wani sabon magani wanda ke daidaita haɓakar hanyoyin sadarwar da ke sarrafa halayen cin abinci zai zama muhimmin mataki don sarrafa wannan kiba mai yaɗuwa. Ƙungiyar binciken ta sami karuwar kiba da nau'in ciwon sukari na II a cikin mutanen da ke da siginar synaptic LPA.
Kungiyar da Farfesa Johannes Vogt (Faculty of Medicine, University of Cologne), Farfesa Robert Nitsch (Faculty of Medicine, Jami'ar Münster) da Farfesa Thomas Horvath (Yale School of Medicine, New Haven, Amurka) ya jagoranci, yanzu ya nuna cewa ikon sarrafawa. Ƙwararrun ƙwayoyin cuta a cikin ƙwayar ƙwayar cuta ta LPA tana taka muhimmiyar rawa wajen sarrafa halayen cin abinci: AgRP neurons suna daidaita adadin lysophosphatidylcholine (LPC) a cikin jini.
Ta hanyar sufuri mai aiki, LPC ya isa kwakwalwa, inda aka canza shi ta hanyar autotaxin enzyme (ATX) zuwa LPA, wanda ke aiki a synapse. Sigina na LPA na Synaptic suna motsa takamaiman cibiyoyin sadarwa a cikin kwakwalwa, don haka yana haifar da haɓakar abinci.
A cikin tsarin linzamin kwamfuta, bayan wani lokaci na azumi karuwa a cikin LPC a cikin jini ya haifar da karuwa a cikin LPA mai motsa jiki a cikin kwakwalwa. Waɗannan berayen sun nuna halaye na neman abinci. Dukansu biyu za a iya daidaita su ta hanyar sarrafa masu hana autotaxin. Mice masu kiba, a gefe guda, sun rasa nauyi lokacin da aka ci gaba da gudanar da waɗannan masu hanawa.
Johannes Vogt, Farfesa a Faculty of Medicine, Jami'ar Cologne:
"Mun ga raguwa mai yawa a cikin yawan abinci da kiba ta hanyar maye gurbin kwayoyin halitta da hana magunguna na ATX."
"Bincikenmu na asali game da haɓakawar kwakwalwar LPA, wanda muka yi aiki akai-akai tsawon shekaru, don haka kuma suna taka muhimmiyar rawa ga halayen cin abinci."
"Mun ga raguwa mai yawa a cikin yawan abinci da kiba ta hanyar maye gurbin kwayoyin halitta da hana magunguna na ATX."
"Bincikenmu na asali game da haɓakawar kwakwalwar LPA, wanda muka yi aiki akai-akai tsawon shekaru, don haka kuma suna taka muhimmiyar rawa ga halayen cin abinci."
Robert Nitsch, Farfesa a Faculty of Medicine, Jami'ar Münster:
"Bayanan sun nuna cewa mutanen da ke da hanyar siginar siginar synaptic LPA suna da yuwuwar yin kiba kuma suna fama da nau'in ciwon sukari na II."
"Wannan alama ce mai ƙarfi na yuwuwar nasarar warkewa na masu hana ATX, wanda a halin yanzu muna haɓaka tare da Cibiyar Hans Knöll a Jena don amfani da ɗan adam."
Wadannan binciken game da kulawar motsa jiki na cibiyoyin sadarwa na neuronal a cikin halayen cin abinci ta hanyar lysophospholipids da kuma sababbin hanyoyin warkewa da suka ba da shawara na iya ba da gudummawa a nan gaba ba kawai don magance matsalar cin abinci ba, har ma da cututtukan zuciya da na tabin hankali.